Acyclovir Prophylaxis Predisposes to Antiviral-Resistant Recurrent Herpetic Keratitis
نویسندگان
چکیده
منابع مشابه
Acyclovir prophylaxis predisposes to antiviral-resistant recurrent herpetic keratitis.
PURPOSE Long-term acyclovir (ACV) prophylaxis, recommended to prevent recurrent herpes simplex virus type 1 (HSV-1) ocular disorders, may pose a risk for ACV-refractory disease due to ACV resistance. We determined the effect of ACV prophylaxis on the prevalence of corneal ACV-resistant (ACV(R)) HSV-1 and clinical consequences thereof in patients with recurrent HSV-1 keratitis (rHK). METHODS F...
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Forty patients with disciform keratitis were randomly assigned to double-blind treatment with 3% acyclovir and 0.01% betamethasone drops or acyclovir and matching placebo. All patients who received the combination healed in a median time of 21 days, while 11 of 19 patients who received acyclovir alone were withdrawn because their condition remained static or worsened (p less than 0.001). The co...
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more potent drugs have become available. Arabinoside adenine and trifluorothymidine (TFT) are both effective and relatively nontoxic alternatives widely used in the management of herpetic disease.' Acyclovir (ACV) (9-(2-hydroxyethoxymethyl) guanine)2 and (E)-5(2-bromovinyl)-2' deoxyuridine),3 recently developed antiviral compounds with potent inhibitory activity against herpes simplex DNA polym...
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PURPOSE To report a case of acyclovir-resistant herpetic keratitis in a solid-organ lung transplant recipient that was effectively treated with topical trifluridine. METHODS A case of a 35-year-old female with herpetic epithelial keratitis resistant to acyclovir is described. The patient presented following treatment for 4 weeks with topical acyclovir ointment five times per day and oral vala...
متن کاملAcyclovir-resistant corneal HSV-1 isolates from patients with herpetic keratitis.
The prevalence and molecular characteristics of isolates from 173 immunocompetent patients with herpetic keratitis (HK) who were infected with acyclovir (ACV)-resistant (ACV(R)) corneal herpes simplex virus (HSV)-1 was determined. Isolates from 11 (6.4%) of the patients were ACV(R), and 9 of these 11 patients were refractory to therapy with ACV; the ACV(R) isolates from 5 and 1 of these 9 patie...
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ژورنال
عنوان ژورنال: The Journal of Infectious Diseases
سال: 2013
ISSN: 1537-6613,0022-1899
DOI: 10.1093/infdis/jit350